Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
- Primary Antibodies ›
- PSD-95 Antibodies
Proteintech
View all (41) PSD-95 antibodies
Cite PSD95/DLG4 Polyclonal Antibody
FIGURE: 1 / 9
{{ $ctrl.currentElement.advancedVerification.fullName }}
{{ $ctrl.currentElement.advancedVerification.text }}
PSD95/DLG4 Antibody (20665-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 20665-1-AP) (PSD95-Specific,DLG4 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
Published figure supplied by
{{$ctrl.videoDesc}}
{{$ctrl.videoLongDesc}}
Product Details
20665-1-AP
Applications
Tested Dilution
Publications
Western Blot(WB)
1:1,000-1:6,000
View 109 publications109 publications
Immunohistochemistry (IHC)
-
View 5 publications5 publications
Immunohistochemistry (Paraffin) (IHC (P))
1:10-1:100
-
Immunocytochemistry(ICC/IF)
-
View 23 publications23 publications
Flow Cytometry(Flow)
-
View 2 publications2 publications
Immunoprecipitation(IP)
0.5-4.0 µg
View 1 publication1 publication
Product Specifications
Species Reactivity
Human,Mouse,Rat
Published species
Hamster,Human,Mouse,Rat
Host/Isotype
Rabbit/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Unconjugated
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase hom*ology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence hom*ology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-hom*otypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases:discs large hom*olog 4; Disks large hom*olog 4; FLJ97752; FLJ98574; post synaptic density; post-synaptic density protein 95; Postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SAP-90; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15
UniProt ID:(Human) P78352, (Rat) P31016, (Mouse) Q62108
Entrez Gene ID:(Human) 1742, (Rat) 29495, (Mouse) 13385
Molecular Function: 
scaffold/adaptor protein
Function(s)
MAPK cascadenegative regulation of receptor internalizationprotein complex assemblysignal transductionpositive regulation of cytosolic calcium ion concentrationchemical synaptic transmissionnervous system developmentlearningsynaptic vesicle maturationion transmembrane transportsocial behaviorprotein localization to synapselocomotory exploration behaviorpositive regulation of GTPase activityestablishment of protein localizationestablishment or maintenance of epithelial cell apical/basal polarityGMP metabolic processGDP metabolic processregulation of long-term neuronal synaptic plasticitypositive regulation of synaptic transmissionneuromuscular process controlling balancedendritic spine morphogenesisvocalization behaviorAMPA glutamate receptor clusteringreceptor localization to synapseregulation of N-methyl-D-aspartate selective glutamate receptor activitypositive regulation of excitatory postsynaptic potentialregulation of grooming behaviorneuronal ion channel clusteringnucleotide phosphorylationlocomotory behaviorresponse to cocaineregulation of neuronal synaptic plasticity
Process(es)
guanylate kinase activityRas guanyl-nucleotide exchange factor activityprotein bindingprotein C-terminus bindingligand-gated ion channel activitykinase bindingprotein phosphatase bindingPDZ domain bindingbeta-1 adrenergic receptor bindingD1 dopamine receptor bindingP2Y1 nucleotide receptor bindingprotein complex bindingacetylcholine receptor bindingionotropic glutamate receptor bindingneuroligin family protein bindingscaffold protein bindingreceptor bindingprotein kinase bindingglutamate receptor bindingstructural molecule activityneurexin family protein binding
It has to be done as per old AB suggested Products section.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
